Zomwe zimapangidwira kukula kochokera ku Platelet SEB-C100
Chiyambi cha malonda
Platelet Derived Growth Factor Analyzer ndi chida choyesera ndi kusanthula kutengera njira yapadera yoyesera yomwe kampani yathu idachita.Wosanthula amazindikira kukula kochokera ku mapulateleti, cholembera cha protein mumkodzo wamunthu chomwe chimapangidwa pamene coronary artery stenosis imachitika.Kusanthula kumatha kutha mphindi zochepa pogwiritsa ntchito 1ml yokha ya mkodzo.Wosanthula amatha kudziwa ngati mitsempha ya coronary ili ndi stenosis komanso kuchuluka kwa stenosis kuti apereke chidziwitso chowunikanso.Njira yodziwira ndi kusanthula kwa ma platelet-derived growth factor analyzer ndi njira yodziwikiratu yosasokoneza, yomwe simafuna jakisoni ndi mankhwala othandizira, kuthetsa vuto loti anthu omwe ali ndi ayodini omwe ali ndi ayodini amalephera kudwala CT ndi matenda ena a coronary. angiography ya mitsempha.The analyzer ali ndi ubwino wa mtengo wotsika kuyesa, osiyanasiyana ntchito, ntchito yosavuta, mofulumira kuyezetsa liwiro, etc., ndipo ndi mtundu watsopano wa coronary artery stenosis kuzindikira msanga ndi kuwunika chida.
Analyzer ali ndi zabwino izi:
1. Kuthamanga: Ikani mkodzo mu chipangizo chozindikirira ndipo ingodikirani mphindi zochepa
2. Kusavuta: Kuyezetsa sikumapezeka muzipatala zokha.Atha kuchitidwanso kumalo oyezetsa matenda, kumalo osungirako anthu okalamba kapena kumalo osamalira anthu ammudzi
3. Chitonthozo: 1ml yokha ya mkodzo ndiyofunika ngati chitsanzo, palibe magazi, palibe mankhwala, palibe jekeseni wosiyana, palibe nkhawa zokhudzana ndi ziwengo.
4. Luntha: Kuyang'ana mokhazikika, kugwira ntchito mosayang'aniridwa
5. Easy einstallation: Small kukula, akhoza kuikidwa ndi ntchito ndi theka tebulo
6. Kukonza kosavuta: Imayang'anira zokha ndikuwonetsa mawonekedwe omwe angagulidwe kuti asinthe mosavuta
Mfundo ya mankhwala
Raman spectroscopy imagwiritsa ntchito kubalalitsa kuwala kuti iwunike mwachangu kapangidwe ka maselo.Njira imeneyi ndi yozikidwa pa mfundo yakuti kuwala kukayatsa molekyu, kugundana kotanuka kumachitika ndipo mbali ina ya kuwalako imabalalika.Kuchuluka kwa kuwala kobalalika kumasiyana ndi kuchuluka kwa kuwala kwa zochitika, komwe kumadziwika kuti Raman kubalalika.Kuchuluka kwa kufalikira kwa Raman kumalumikizana ndi kapangidwe ka molekyulu, kulola kusanthula mphamvu yake komanso kuchuluka kwake kuti mudziwe bwino momwe mamolekyu amakhalira.
Chifukwa cha kufooka kwa siginecha ya Raman komanso kusokoneza pafupipafupi kwa fluorescence, kupeza mawonekedwe a Raman pakuzindikira kwenikweni kungakhale kovuta.Kuzindikira bwino chizindikiro cha Raman ndikovuta.Chifukwa chake, mawonekedwe owoneka bwino a Raman amatha kukulitsa kukula kwa kuwala kwa Raman, kuthana ndi izi.Mfundo yofunika kwambiri pa kachipangizoka imakhudza kuyika chinthucho kuti chiziwidwa pazitsulo zapadera, monga siliva kapena golide.kuti apange malo owoneka bwino, okhala ndi nanometer, zomwe zimapangitsa kuti pakhale mawonekedwe owonjezera.
Zinawonetsedwa kuti mawonekedwe a Raman a marker platelet-derived growth factor (PDGF-BB) anali ndi nsonga yodziwika bwino pa 1509 cm-1.Kupitilira apo, zidadziwika kuti kupezeka kwa marker platelet-derived growth factor (PDGF-BB) mu mkodzo wolumikizidwa ndi coronary artery stenosis.
Pogwiritsa ntchito ukadaulo wa Raman spectroscopy ndi ukadaulo wowonjezera pamwamba, chowunikira cha PDGF chimatha kuyeza kupezeka kwa PDGF-BB ndi kuchuluka kwake kwamphamvu mumkodzo.Izi zimathandiza kudziwa ngati mitsempha yam'mitsempha yamagazi ndi stenotic komanso kuchuluka kwa stenosis, motero kumapereka maziko ozindikira matenda.
Mbiri ya mankhwala
M'zaka zaposachedwapa, kufalikira kwa matenda a mtima kumawonjezeka pang'onopang'ono chifukwa cha kusintha kwa zakudya ndi zizoloŵezi za moyo, komanso anthu okalamba.Chiwopsezo cha kufa chokhudzana ndi matenda amtima chimakhalabe chokwera mochititsa mantha.Malinga ndi lipoti la China Cardiovascular Health and Disease Report 2022, chiwerengero cha anthu omwe amafa ndi matenda a mtima pakati pa anthu okhala m'matauni a ku China adzakhala 126.91 / 100,000 ndi 135.88 / 100,000 pakati pa anthu akumidzi mu 2020. Chiwerengerochi chakwera kwambiri kuyambira 2012 kumidzi.Mu 2016, idaposa kuchuluka kwa mizinda ndikupitilira kukwera mu 2020. Pakalipano, coronary arteriography ndiyo njira yoyamba yodziwira matenda yomwe imagwiritsidwa ntchito pazachipatala kuti azindikire matenda amtima.Ngakhale kuti amatchedwa "gold standard" pakuzindikiritsa matenda a mtima, kuwonongeka kwake komanso kukwera mtengo kwapangitsa kuti electrocardiography isinthe pang'onopang'ono.Ngakhale kuti electrocardiogram (ECG) kufufuza ndi kosavuta, kosavuta, komanso kotsika mtengo, kufufuza molakwika ndi kulephera kuzindikira kungachitikebe, zomwe zimapangitsa kuti zikhale zosadalirika pa matenda a matenda a mtima.Choncho, chitukuko cha njira yosasokoneza, yowonongeka kwambiri, komanso yodalirika yodziwira msanga komanso mwamsanga matenda a mtima ndi ofunika kwambiri.
Raman spectroscopy yowonjezera pamwamba (SERS) yapeza kugwiritsidwa ntchito kofala mu sayansi ya moyo pozindikira ma biomolecules pamalo otsika kwambiri.Mwachitsanzo, Alula et al.Anatha kuzindikira milingo ya miniti ya creatinine mumkodzo pogwiritsa ntchito ma SERS spectroscopy okhala ndi zithunzi zosinthidwa mothandizidwa ndi nanoparticles zasiliva zomwe zimakhala ndi maginito.
Mofananamo, Ma et al.adagwiritsa ntchito maginito ophatikizira ma nanoparticles mu SERS spectroscopy kuti awulule kutsika kwambiri kwa deoxyribonucleic acid (DNA) mu mabakiteriya.
Platelet-derived growth factor-BB (PDGF-BB) imathandizira kwambiri pakukula kwa atherosulinosis kudzera munjira zingapo ndipo imakhala yolumikizana kwambiri ndi matenda amtima.Enzyme-linked immunosorbent assay (ELISA) ndiye njira yayikulu yomwe imagwiritsidwa ntchito pa kafukufuku waposachedwa wa PDGF-BB pozindikira mapuloteniwa m'magazi.Mwachitsanzo, Yuran Zeng ndi anzawo adatsimikiza kuchuluka kwa plasma kwa PDGF-BB pogwiritsa ntchito ma enzyme-linked immunosorbent assay ndipo adazindikira kuti PDGF-BB imathandizira kwambiri pathogenesis ya carotid atherosclerosis.Mu kafukufuku wathu, tidasanthula kaye mawonekedwe a SERS amitundu yosiyanasiyana yamadzi a PDGF-BB okhala ndi otsika kwambiri, pogwiritsa ntchito nsanja yathu ya 785 nm Raman spectroscopy.Tidapeza kuti nsonga zapamwamba zokhala ndi kusintha kwa Raman kwa 1509 cm-1 zidatumizidwa ku yankho lamadzi la PDGF-BB.Kuphatikiza apo, tapeza kuti nsonga zapamwambazi zidalumikizidwanso ndi yankho lamadzi la PDGF-BB.
Kampani yathu inagwirizana ndi magulu ofufuza a ku yunivesite kuti achite kafukufuku wa SERS pamikodzo 78 yonse.Izi zinaphatikizapo zitsanzo za 20 kuchokera kwa odwala omwe anachitidwa opaleshoni ya PCI, zitsanzo za 40 kuchokera kwa odwala omwe sanachite opaleshoni ya PCI, ndi zitsanzo za 18 kuchokera kwa anthu athanzi.Tidasanthula mosamalitsa mawonekedwe a mkodzo a SERS pophatikiza nsonga za Raman ndi kusintha kwa Raman pafupipafupi kwa 1509cm-1, komwe kumalumikizidwa mwachindunji ndi PDGF-BB.Kafukufukuyu adawonetsa kuti zitsanzo za mkodzo wa odwala omwe anachitidwa opaleshoni ya PCI anali ndi chiwerengero chodziwika bwino cha 1509cm-1, pamene chiwerengerochi sichinalipo mu zitsanzo za mkodzo wa anthu athanzi komanso odwala ambiri omwe sanali PCI.Panthawi imodzimodziyo, pamene chidziwitso chachipatala cha chipatala cha coronary angiography chinaphatikizidwa, zinatsimikiziridwa kuti njira yodziwikirayi ikugwirizana bwino ndi kudziwa ngati pali kutsekeka kwa mtima kupitirira 70%.Komanso, njira imeneyi akhoza kuzindikira ndi tilinazo ndi mwachindunji 85% ndi 87% motero, mlingo wa blockage wamkulu kuposa 70% mu milandu ya mtsempha wamagazi matenda ndi kuzindikira khalidwe nsonga za Raman wa 1509 cm-1.5%, motero, njira iyi ikuyembekezeka kukhala maziko ofunikira posankha ngati odwala omwe ali ndi matenda amitsempha yamagazi amafunikira PCI, zomwe zimapereka chidziwitso chothandiza kwambiri pakuzindikira koyambirira kwa omwe akukayikira kuti ali ndi matenda a mtima.
Potengera izi, kampani yathu yakhazikitsa zotsatira za kafukufuku wathu wakale poyambitsa Platelet Derived Growth Factor Analyzer.Chipangizochi chidzasintha kwambiri kukwezedwa ndi kugwiritsidwa ntchito kwakukulu kwa matenda oyambirira a mtima.Zithandizira kwambiri kukonza thanzi la mtima wamtima ku China komanso padziko lonse lapansi.
Zolemba
[1] Huinan Yang, Chengxing Shen, Xiaoshu Cai et al.Kuzindikira kosavutikira komanso koyembekezeka kwa matenda amtima ndi mkodzo pogwiritsa ntchito mawonekedwe owoneka bwino a Raman [J].Katswiri, 2018, 143, 2235-2242.
Mapepala a parameter
| nambala yachitsanzo | Mtengo wa SEB-C100 |
| chinthu choyesera | Kuchuluka kwa ma platelet-derived growth factor nsonga za mkodzo |
| Njira Zoyesera | zochita zokha |
| Chiyankhulo | Chitchainizi |
| Kuzindikira Mfundo | Raman spectroscopy |
| kuyankhulana mawonekedwe | Micro USB Port, Network Port, WiFi |
| zobwerezedwa | Kuchuluka kwa kusiyana kwa zotsatira za mayeso ≤ 1.0% |
| mlingo wolondola | Zotsatira zimagwirizana kwambiri ndi zitsanzo za miyeso yofanana. |
| bata | Coefficient of variable ≤1.0% ya chitsanzo chomwecho mkati mwa maola 8 a kuyatsa |
| Njira yojambulira | Chiwonetsero cha LCD, FlashROM yosungirako deta |
| nthawi yozindikira | Nthawi yodziwika yachitsanzo chimodzi ndi yochepera masekondi 120 |
| Mphamvu Yogwira Ntchito | adaputala mphamvu: AC 100V ~ 240V, 50/60Hz |
| miyeso yakunja | 700mm(L)*560mm(W)*400mm(H) |
| kulemera | Pafupifupi 75kg |
| malo ogwira ntchito | ntchito kutentha: 10 ℃ ~ 30 ℃;chinyezi wachibale: ≤90%;kuthamanga kwa mpweya: 86kPa～106kPa |
| Mayendedwe ndi malo osungira | kutentha kwa ntchito: -40 ℃～55 ℃;chinyezi wachibale: ≤95%;kuthamanga kwa mpweya: 86kPa～106kPa |
