Njira Yowongoleredwa Yolosera Chiwopsezo cha Matenda a Mitsempha ya Coronary

MyOme anapereka deta kuchokera ku chithunzi pamsonkhano wa American Society of Human Genetics (ASHG) womwe unayang'ana pa Integrated Polygenic Risk Score (caIRS), yomwe imaphatikiza majini ndi chikhalidwe chachipatala kuti adziwe bwino anthu omwe ali pachiopsezo chachikulu cha matenda a mitsempha ya mitsempha. (CAD) kudutsa anthu osiyanasiyana.

Zotsatirazi zikuwonetsa kuti caIRS idazindikiritsa molondola anthu omwe ali pachiwopsezo chachikulu chotenga matenda a mtima, makamaka m'malire kapena magulu apakatikati omwe ali pachiwopsezo chachipatala komanso kwa anthu aku South Asia.

Mwachizoloŵezi, zida zambiri zowunikira zoopsa za CAD zatsimikiziridwa pa anthu ochepa, malinga ndi Akash Kumar, MD, PhD, mkulu wa zamankhwala ndi sayansi wa MyOme.Chida chomwe chimagwiritsidwa ntchito kwambiri, Atherosclerotic Cardiovascular Disease (ASCVD) Pooled Cohort Equation (PCE), chimadalira miyeso yofanana ndi cholesterol ndi matenda a shuga kulosera za ngozi ya CAD ya zaka 10 ndikuwongolera zisankho zokhudzana ndi kuyambika kwa chithandizo cha statin, adatero Kumar. .

Amaphatikiza mamiliyoni amitundu yosiyanasiyana

Polygenic risk scores (PRS), yomwe imaphatikiza mamiliyoni amitundu yosiyanasiyana yamitundu yaying'ono kukhala gawo limodzi, imapereka mwayi wowongolera kulondola kwa zida zowunikira zoopsa zachipatala," adapitiliza Kumar.MyOme yapanga ndikutsimikizira chiwerengero cha chiopsezo chophatikizika chomwe chimaphatikiza PRS yamitundu yosiyanasiyana ndi caIRS.

Zotsatira zazikuluzikulu zomwe zafotokozedwazo zikuwonetsa kuti caIRS idakulitsa tsankho poyerekeza ndi PCE m'magulu onse ovomerezeka ndi makolo omwe adayesedwa.CaIRS idazindikiranso milandu yowonjezereka ya 27 ya CAD pa anthu 1,000 omwe ali m'malire / gulu lapakati la PCE.Kuphatikiza apo, anthu aku South Asia adawonetsa kuwonjezereka kwakukulu kwa tsankho.

"Kuphatikizika kwachiwopsezo cha MyOme kumatha kupititsa patsogolo kupewa ndi kuwongolera matenda mkati mwa chisamaliro choyambirira pozindikira anthu omwe ali pachiwopsezo chachikulu chokhala ndi CAD, omwe mwina akanaphonya," adatero Kumar."Chodziwika bwino, caIRS inali yothandiza kwambiri pozindikira anthu aku South Asia omwe ali pachiwopsezo cha CAD, zomwe ndi zofunika kwambiri chifukwa cha kufa kwawo pafupifupi kawiri poyerekeza ndi aku Europe."

Chiwonetsero cha poster cha Myome chinali ndi mutu wakuti "Kuphatikizana kwa Polygenic Risk Scores ndi Clinical Factors Kupititsa patsogolo Kuneneratu Zowopsa za Zaka 10 za Coronary Artery Disease."